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The Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) may be “an important moderator” of clinical and tau outcomes in people with dominantly inherited Alzheimer’s disease (DIAD), say researchers.

Findings from The Children’s Oncology Group AAML1331 study suggest that all-trans retinoic acid (ATRA) and arsenic trioxide may be able to reduce or eliminate the need for cytotoxic chemotherapy in children and young adults with a new diagnosis of acute promyelocytic leukaemia (APL).

Introduction of a screening protocol for autism spectrum disorder (ASD) increases the rate of diagnosis, with Spanish-speaking families being the greatest beneficiaries, report researchers.

Plasma levels of phosphorylated (p)-tau proteins could serve as a biomarker for cognitive decline in individuals with dementia with Lewy bodies (DLB), say researchers who found an association between increasing levels of the proteins and more rapid decline in Mini-Mental State Examination (MMSE) scores over time.