HLA-A*03 alleles linked to poor ICI therapy response

Carriage of a specific human leukocyte antigen (HLA) allele is associated with a poor response to immune checkpoint inhibitor (ICI) therapy in patients with a range of tumour types, suggests research published in The Lancet Oncology.
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Mortality rates remain elevated in patients with SLE, scleroderma

People with systemic lupus erythematosus (SLE) or scleroderma had a significantly higher risk for all-cause mortality than the general population in 2015–2019, with the greatest excess risk seen in men and younger patients, suggest findings from a large study published in RMD Open.
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High prevalence of multifocal disease highlighted for paediatric papillary thyroid carcinoma

Research points to a high prevalence of multifocal disease in children with papillary thyroid carcinoma (PTC), with age and tumour stage possible risk factors for this diagnosis. Maisie Shindo, from Oregon Health & Science University in Portland, USA, and colleagues report their findings in JAMA Otolaryngology – Head & Neck Surgery from a cohort study of 212 patients aged up to 18 years who underwent thyroidectomy at one of five US hospitals between 2010 and 2020.
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