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Children diagnosed with attention deficit/hyperactivity disorder (ADHD) before puberty have evidence of changes in their gut microbiota before the age of 1 year, research shows.

A night-time only infusion of the dopamine agonist apomorphine could help to reduce sleep disturbances in patients with advanced Parkinson’s disease and moderate-to-severe insomnia, suggest the results of the APOMORPHEE trial.

Researchers have identified an association between faster rates of increase of TREM2 levels in soluble cerebrospinal fluid (CSF) and slower progression of several markers of disease evolution in participants of the Dominantly Inherited Alzheimer Network (DIAN), which they say points to a likely protective effect of TREM2 during the early pathogenesis of Alzheimer’s disease.

Children undergoing treatment for cancer report significantly more symptomatic adverse events (AEs) than their clinicians but fewer than their caregivers, suggests research comparing assessments for triads of patients, caregivers and clinicians.