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FOLFIRINOX (folinic acid, fluorouracil, irinotecan hydrochloride and oxaliplatin) chemotherapy may offer better survival than gemcitabine plus nab-paclitaxel for patients with metastatic pancreatic ductal adenocarcinoma, suggests a comparative effectiveness study published in JAMA Network Open.

UK researchers have a calculated a “time to cure” of around 6 years after diagnosis for children and young adults with acute lymphoblastic leukaemia (ALL), regardless of risk status. “Knowing when patients with ALL are cured will allow their timely transfer to clinics devoted to monitoring long-term morbidity rather than relapse and facilitates communication to patients and families”, say Ajay Vora (Great Ormond Street Hospital, London) and colleagues in the Journal of Clinical Oncology.

Researchers find a high burden of non-specific persistent symptoms in children aged 14 years or younger, with SARS-CoV-2 infection adding to this only slightly.

Genetic testing can identify an underlying cause in more than half of complex/syndromic infants with congenital diaphragmatic hernia (CDH), but factors underlying isolated cases remain elusive, say researchers.