13 mai 2022
A night-time only infusion of the dopamine agonist apomorphine could help to reduce sleep disturbances in patients with advanced Parkinson’s disease and moderate-to-severe insomnia, suggest the results of the APOMORPHEE trial.
9 mai 2022
Study findings suggest that higher blood neutrophil counts and neutrophil-to-lymphocyte ratio (NLR) are associated with an increased risk for disease progression and mortality in patients with early systemic sclerosis (SSc).
3 mai 2022
Researchers have identified an association between faster rates of increase of TREM2 levels in soluble cerebrospinal fluid (CSF) and slower progression of several markers of disease evolution in participants of the Dominantly Inherited Alzheimer Network (DIAN), which they say points to a likely protective effect of TREM2 during the early pathogenesis of Alzheimer’s disease.
25 avril 2022
Autoantibodies against interleukin-1 receptor antagonist (IL-1Ra) are present in a large proportion of patients with multisystem inflammatory syndrome in children (MIS-C), say researchers.
19 avril 2022
Children undergoing treatment for cancer report significantly more symptomatic adverse events (AEs) than their clinicians but fewer than their caregivers, suggests research comparing assessments for triads of patients, caregivers and clinicians.
12 avril 2022
Among patients with systemic lupus erythematosus (SLE), glycosylation patterns of anti-double-stranded (ds)DNA immunoglobulin (Ig)G autoantibodies differ from those of total IgG and correlate with disease activity, suggests research published in eBioMedicine.
4 avril 2022
Serum levels of neurofilament light (sNfL) protein are elevated in both the pre-ataxic and ataxic stages of spinocerebellar ataxia type 1 (SCA1), and are associated with onset of ataxia, shows research published in Neurology.
28 mars 2022
Child, adolescent and young adult survivors of childhood cancer do not have a greater risk of COVID-19 infection and severe illness than individuals without a history of cancer, suggest findings from a population-based study published in the Journal of Clinical Oncology.
21 mars 2022
Replacement of the enzymes lacking in Tay–Sachs disease (TSD) using adeno-associated virus gene therapy via both the thalamus and cerebrospinal fluid (CSF) is possible and potentially efficacious in humans, shows a study in Nature Medicine.
14 mars 2022
A single infusion of allogeneic bone marrow-derived mesenchymal stromal cells (MSCs) was well tolerated and showed preliminary efficacy for severe diffuse systemic sclerosis (SSc) in a phase 1/2 proof-of-concept study by Dominique Farge (Hôpital St-Louis, Paris, France) and colleagues.