Sepsis is a clinical syndrome characterized by intense and dysregulated activation of the immune system during infection. It is a major public health issue with a high prevalence and high mortality. Fil Swirski’s team (Boston, USA) has discovered a new sub-type of B lymphocytes: innate response activator B cells (IRA B cells). IRA B cells play a key role during sepsis and produce growth factors such as granulocyte-macrophage colonystimulating factor (GM-CSF) and interleukin-3 (IL-3). We studied the precise role of these molecules during sepsis and showed that IRA B cells have a complex double-faced role in the pathophysiology of this clinical syndrome. These discoveries pave the way to the identification of potential new therapeutic targets to treat this scourge.
2016Download the publication