Abstract

Sepsis is a clinical syndrome characterized by intense and dysregulated activation of the immune system during infection. It is a major public health issue with a high prevalence and high mortality. Fil Swirski’s team (Boston, USA) has discovered a new sub-type of B lymphocytes: innate response activator B cells (IRA B cells). IRA B cells play a key role during sepsis and produce growth factors such as granulocyte-macrophage colonystimulating factor (GM-CSF) and interleukin-3 (IL-3). We studied the precise role of these molecules during sepsis and showed that IRA B cells have a complex double-faced role in the pathophysiology of this clinical syndrome. These discoveries pave the way to the identification of potential new therapeutic targets to treat this scourge.

Author
Benjamin Glenn Chousterman
Author
Benjamin Glenn Chousterman
Category
Immunoinflammatory
Publication type
Abstract
Year
2016
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