A recent study conducted by Washington State University demonstrates the efficacy of soy in the post-operative treatment of bone cancer.
Bone cancers are extremely painful diseases requiring extensive treatment
Most of the time, bone cancers are metastases, or secondaries, of other cancers, such as lung, kidney, breast and thyroid cancers. More rarely, bone cancers can also be primary cancers of bone tissue. They generally affect young adults or children. Currently, the treatment of bone cancers is based on surgery to remove tumors from bone tissue, accompanied by pre- and post-operative chemotherapy sessions.1 The surgical removal of parts of bone and replacement with prostheses can cause painful inflammation in patients. The aim of the American researchers is to find a gentler and less painful post-operative treatment.
According to a recent American study, soy proteins could be used as a post-operative treatment in bone cancer
American scientists have recently published their study in the specialized international journal, Acta Biomateralia. To carry out their study, the researchers used 3D printing to make scaffolds very similar to the bones of cancer patients. They incorporated three primary soy isoflavones inside the scaffolds: genistein, daidzein and glycitein. These soy proteins were then placed in samples containing cancer cells. After a period of only 11 days, the researchers observed that genistein reduced the viability of cancer cells by 90% and the other two isoflavones increased the growth of healthy cells within the tissues.
The study also demonstrates the anti-inflammatory role of soy isoflavones. After 24 hours, the researchers observed the recruitment of neutrophils at the surgical site in a mouse distal femur model.2
According to the American scientists, these results in animals are invaluable and encouraging. The make it possible to better identify therapeutic approaches for bone cancers and to seek natural treatments with fewer side effects for patients.
Sarkar N, Bose S. Controlled release of soy isoflavones from multifunctional 3D printed bone tissue engineering scaffolds. Acta Biomater. 2020 Sep 15;114:407-420. doi: 10.1016/j.actbio.2020.07.006. Epub 2020 Jul 8. PMID: 32652224